Pathways
RAR-Gamma-RXR-Alpha Degradation
Description:
In response to Retinoic Acid (a metabolite of Vitamin-A (all-trans-Retinol), which affects gene transcription), target genes are regulated by two families of nuclear receptors, the RARs (Retinoic Acid Receptors) and the RXRs (Retinoid X Receptors) that bind as RAR/RXR heterodimers to response elements located in their promoters. The all-trans-Retinoic Acid, the Carboxylic Acid form of Vitamin-A is of biological significance since it is predominant under most physiological situ...
References:
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Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure.
Clin Cancer Res. 2009 Oct 15;15(20):6321-6. doi: 10.1158/1078-0432.CCR-09-0209. Epub 2009 Oct 6. Review. -
The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.
Nat Commun. 2017 Oct 11;8(1):868. doi: 10.1038/s41467-017-00981-y. -
Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor β/δ (PPARβ/δ).
J Biol Chem. 2012 Dec 7;287(50):42195-205. doi: 10.1074/jbc.M112.410381. Epub 2012 Oct 26. -
Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations.
Cells. 2019 Nov 5;8(11). pii: E1392. doi: 10.3390/cells8111392.
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